Alzheimer's Disease Center
University of California, Davis
The Family Connection
Estrogen and Alzheimer's Disease
The UC Davis Alzheimer's Disease Center in Martinez, in collaboration with 40 centers nationwide, is recruiting women to participate in the study of estrogen in the treatment of Alzheimer's disease. The study will examine the effects of estrogen on the prevention and progression of Alzheimer's disease.
More than 120 women are needed to participate in the 15 month project to see whether estrogen affects memory and other mental abilities such as the learning process. Estrogen may also have mood enhancing effects and this improvement in mood may elevate memory and increase the quality of life.
Volunteers must be at least 60 years old with a diagnosis of mild to moderate Alzheimer's disease and have had a hysterectomy. Participants will be followed closely and will attend clinic visits at two, six, nine, 12 and 15 months. Clinic visits may include lab tests, EKGs, brain scans, mammograms and pelvic exams.
"Currently evidence that relates to estrogen and Alzheimer's disease has been epidemiological and little is understood about the relationship," says study coordinator Robin Ketelle, R.N. "This study specifically looks at the possible impact of estrogen on Alzheimer's disease."
This is the first study of its kind in collaboration with the Alzheimer's Disease Center Cooperative Study Unit, funded by the National Institutes of Health, to study the effects of estrogen and Alzheimer's disease. In the past, studies of Alzheimer's drug treatments have been funded by drug companies and have looked at estrogen in combination with other hormones.
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