General Description of MCI

 

Published Research by Center Investigators

1. Du AT, Shuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, Yaffe K, Kramer JH, Reed B, Norman D, Chui HC, Weiner MW. (2001). MRI of entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 71:441-447.

2. Bennett, D.A., Wilson, R.S., Schneider, J.A., Evans, D.A., Beckett, L.A., Aggarwal, N.T., Barnes, L.L., Fox, J.H., & Bach J. (2002).  Natural history of mild cognitive impairment in older persons. Neurology, 59:198-205.

3. DeCarli C. (2003)  Defining Mild Cognitive Impairment: Prevalence, Prognosis, Etiology and Treatment.  Lancet Neurology, 2(1): 15-21.

4. DeKosky, S.T., Ikonomovic, M.D., Styren, S.D., Beckett, L., Wisniewski, S., Bennett, D.A., Cochran, E.J., Kordower, J.H., & Mufson, E.J. (2002). Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol, 51(2):145-55.

5. Grundman, M., Jack, C.R., Petersen, R.C., Kim, H.T., Taylor, C., Datvian, M., Weiner, M.F., DeCarli, C., DeKosky, S.T., van Dyck, C., Darvesh, S., Yaffe, K., Kaye, J., Thomas, R.G., & Thal, L.J. (2002).  Hippocampal volume is associated with memory but not non-memory cognitive performance in patients with mild cognitive impairment.  Journal Molecular Neuroscience, 19(1-2):23-28.

6. Lopez, O.L., Jagust, W.J.,  DeKosky, S.T., Becker, J.T., Fitzpatrick, A., Dulberg, C., Breitner, J., Lyketsos, C., Jones, B., Kawas, C., Carlson, M., & Kuller, L.H. (2003).  Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. Arch Neurol, 60(10): 1385-9.

7. DeCarli, C., Mungas, D., Harvey, D., Reed, B., Weiner, M., Chui, H., & Jagust, W.  Memory impairment predicts conversion to dementia amongst MCI patients with and without lacunar infarction. Neurology, 63:220–227.

 

New Published Findings

 

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen R. C., Thomas R. G., Grundman M., Bennett D., Doody R., Ferris S., Galasko D., Jin S., Kaye J., Levey A., Pfeiffer E., Sano M., van Dyck C. H., Thal L. J., the Alzheimer's Disease Cooperative Study Group
 
N Engl J Med 2005; published at www.nejm.org on Apr 13, 2005 (10.1056/NEJMoa050151). Original Articles

 

Editorial to the above article

Mild Cognitive Impairment -- No Benefit from Vitamin E, Little from Donepezil
Blacker D.
 
N Engl J Med 2005; published at www.nejm.org on Apr 13, 2005 (10.1056/NEJMe058086). Editorials