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INVESTIGATORS


Charles DeCarli, M.D.
Center Director
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Dr. DeCarli has a strong interest in behavioral neurology, with specific emphasis on dementing disorders, including degenerative dementias such as Alzheimer's disease and frontal dementias. He also focuses on dementias related to movement disorders and vascular disease as well as cognitive impairment after closed head injury. Dr. DeCarli's research interests are divided into two areas: using neuroimaging techniques to understand the relation between brain structure and function with aging and disease, and studying the role of brain antioxidant systems, primarily quinone oxidoreductase, on the pathophysiology and potential treatment of Alzheimer's disease. Dr. DeCarli has published extensively in his field and holds a patent for his method of quantification of brain volumes from magnetic resonance images.


Dan M. Mungas , Ph.D.
Associate Clinical Director, Sacramento
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Dr. Mungas is a recognized authority in the diagnosis and treatment of senile dementia and Alzheimer's disease. He is involved with the Neuropsychology Program in the Department of Neurology and provides neuropsychological assessment services for a broad range of ages and presenting problems. Dr. Mungas is the principal investigator for the Sacramento Alzheimer's Research Center of California and is also working on a research grant to develop English and Spanish neuropsychological tests for the elderly.


Bruce R. Reed , Ph.D.
Associate Clinical Director, Martinez
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Dr. Reed is a recognized expert in the assessment/management of dementing illness. He has published numerous articles on the early detection and prognosis of dementia as well as its anatomic basis of cognitive impairments and behavior disturbance. Dr. Reed is a staff psychologist for the Department of Veterans Affairs in Martinez, guest scientist for the Center for Functional Imaging at Lawrence Berkeley Laboratory, and board member for Alzheimer's Services of the East Bay. He reviews numerous publications, including Neurology, Journal of the Neuropsychological Society, Neuropsychiatry, and Behavioral Neurology.


William Ellis, M.D.
Pathology
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Dr. Ellis specializes in fetal/pediatric neuropathology, teratology, normal brain development, pathology of nervous system aging, Down syndrome dementia, Alzheimer's disease and other neurogenerative diseases, and muscle pathology. He has collaborated on studies of Parkinson's disease, schizophrenia, senile dementia, and early Alzheimer's lesions in young Down syndrome patients.


Laurel A. Beckett , Ph.D.
Biostatistics

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Dr. Beckett is a biostatistician with extensive experience in medical research. She works with scientists in designing, evaluating and analyzing a wide range of studies, including clinical trials, population health studies and basic science investigations. Her areas of specialty include Alzheimer's disease, Parkinson's disease, chronic diseases of aging and cancer clinical trials. She has held consulting positions with Stanford Medical School, the New York Public Health Department, and Brookhaven National Laboratory. She is also a member of the scientific advisory board for the Alzheimer's Disease Center at Johns Hopkins and a reviewer for the Journal of the American Statistical association, the Journal of Gerontology and the Annals of Epidemiology. A research specialist, Dr. Beckett does not see patients.

Danielle Harvey, Ph.D.
Biostatistics
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Dr. Harvey is an Assistant Adjunct Professor, UC Davis, Department of Epidemiology & Preventive Medicine, Division of Biostatistics. Her interests include: Survival analysis, correlated event times, informative censoring, repeated measures, computational methods, and high-dimensional data as in MRI or PET scans. Collaborative research includes work on Alzheimer's, cancer, end-of-life care, dosing errors, and health services and public health issues.



W. Ladson  Hinton, M.D.
Education & Information Core
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Dr. Hinton was formerly a Department of Social Medicine instructor at Harvard Medical School, where he conducted research on family caregiving to elders with dementing illness in a multiethnic sample. Dr. Hinton is studying the role of family and psychosocial factors in cognitive impairment among Latino elders in Sacramento. He has also published several articles on Vietnamese refugee mental health and authored 14 articles and book chapters.



Sarah Tomaszewski Farias, Ph.D.
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Dr. Tomaszewski Farias is an Assistant Professor in the Department of Neurology. Her primary research interests include studying the relationship between cognition, markers of disease (as measured by structural and functional neuroimaging) and everyday functioning within older adult populations. Related areas of interest include examining variables that predict differences in patient versus informant reported cognitive and functional impairments, issues of how to standardize the quantification of functional impairment and disability in MCI, and the influence of non-cognitive variables (behavioral/neuropsychiatric) on everyday function in older adults.

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